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Soluble HLA‐G (sHLA‐G) levels in human seminal plasma (SP) can be diverse and may affect the establishment of maternal‐fetal tolerance and thereby the outcome of pregnancy. We investigated whether sHLA‐G levels in SP are associated with polymorphisms in the 3′‐untranslated region (UTR) and UTR haplotypes of the HLA‐G gene. Furthermore, we compared the HLA‐G genotype distribution and sHLA‐G levels...
Allele‐level HLA compatibility in cord blood transplantation has been associated with better transplant outcomes and is recommended as a selection criterion. It is also a crucial aspect for other therapeutic applications involving cord blood‐derived cells. Determination of high‐resolution HLA frequencies is an important step towards improving the quality of cord blood banks. We analyzed HLA‐A, ‐B,...
In this report, we describe a case of somatic mutations in the two HLA‐B genes in a patient with acute myelogenous leukemia. The HLA‐B*15:01 allele showed an insertion of two nucleotides within exon 2 leading to a premature stop codon. HLA‐B*40:01 showed one nucleotide substitution within exon 3, identical to that described for B*15:258N. The restriction of these mutations in leukemic cells was confirmed...
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